LAS VEGAS — Jose Valenzuela defeated Edwin De Los Santos by second-round knockout on June 28, 2026, at Zuffa Boxing 8. The event took place at The Cosmopolitan in Las Vegas, Nevada.

The stoppage in the main event occurred at 2:05 of round two. Referee Thomas Taylor officiated the bout. This fight was a rematch of their encounter on September 4, 2022.

In their 2022 meeting, Edwin De Los Santos, from Santo Domingo in the Dominican Republic, had defeated Jose Valenzuela via third-round knockout. Both boxers hit the canvas during that previous fight. Valenzuela, 27 years old and from Los Mochis, Mexico, holds a professional record of 16 wins and 3 losses with 10 knockouts. De Los Santos is 26 years old.

Valenzuela described his growth between the two fights. "I was a kid, I was a boy when we first fought. I grew up," Valenzuela stated. He added that he matured and evolved, saying, "I matured a lot and I evolved. You can better yourself and get better. You can lose and come back and become a better fighter and human being and that's what I did."

Valenzuela discussed the fight dynamics, stating, "In the first round, he timed me with a couple good jabs. But when we traded left hands at the end of the first round, I hurt him. And I saw that in the second round, he didn't want to engage. He was hurt so I knew I had to get him and jump on him before he recovered."

Looking ahead, Valenzuela expressed interest in facing another boxer. "I want Shakur Stevenson. He's a hell of a fighter and I would love to compete with him," Valenzuela said. Regarding a potential third fight with De Los Santos, Valenzuela said, "I would love a bigger fight [rather than a trilogy with De Los Santos]. After I took a loss with him, I went on my own journey and became a world champion. Maybe he has some work to do but I'm on to bigger and better things."