The Devil Wears Prada 2 opened to $77 million at the North American box office and $156.6 million internationally for a $233 million worldwide debut. The sequel from The Walt Disney Company's 20th Century Studios was the only major new release in theaters during its opening weekend.

The film took the top spot on its first day with $32.5 million and played in 4,150 locations across North America. Produced on a reported budget of $100 million, it was directed by David Frankel and written by Aline Brosh McKenna.

The opening surpassed Mamma Mia: Here We Go Again, which debuted at $90 million worldwide in 2018, to become the highest opening weekend for a Meryl Streep film by every metric. It also ranked as the biggest international and global launch for Emily Blunt, topping Oppenheimer's $180.4 million worldwide opening weekend, and outgrossed last year's summer kickoff Marvel movie, Thunderbolts.

The original film opened domestically with $27.5 million in June 2006 and grossed more than $326 million worldwide unadjusted for inflation. Women comprised about 76% of ticket buyers for the sequel and 74% said they would definitely recommend it to friends, according to PostTrak exit polls. Audiences awarded the film an "A-" grade on CinemaScore exit polls.

"This is a really solid weekend. It's this irresistible combination that more than makes up for the fact that there's not a Marvel movie to kick off the summer movie season," Paul Dergarabedian, head of marketplace trends for Comscore, said. North American box office revenue is running about 14% above 2024 levels, with approximately $2.8 billion in domestic ticket sales to date.

Stars Streep, Anne Hathaway, Blunt and Stanley Tucci made promotional appearances in Tokyo, London and New York ahead of the release. Anna Wintour appeared with Hathaway on the Oscars stage and with Streep on the cover of Vogue to promote the sequel.

Frankel said, "By the time you finish paying all the biggest movie stars in the world, you still end up with basically the same budget for making the movie as we did the first one." Streep said, "They went right away and said sure," and added, "I'm 50, 60 — it took me this long to understand that I could do that."