Mitragynine pseudoindoxyl is chemically identified as Methyl (E)-2-((1′S,6′S,7′S)-6′-ethyl-4-methoxy-3-oxo-3′,5′,6′,7′,8′,8a′-hexahydro2′H-spiro[indoline-2,1′-indolizine]-7′-yl)-3-methoxyacrylate. MGM-15 is chemically identified as Methyl (E)-2-((2S,3S,7aS,12aR,12bS)-3-ethyl-7a-hydroxy-8-methoxy1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo[2,3-a]quinolizin-2-yl)-3methoxyacrylate and is also known as dihydro-7-hydroxymitragynine. MGM-16 is chemically identified as Methyl (E)-2-((2S,3S,7aS,12aR,12bS)-3-ethyl-9-fluoro-7a-hydroxy-8-methoxy1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo[2,3-a]quinolizin-2-yl)-3methoxyacrylate and is also known as 9-fluorodihydro-7-hydroxymitragynine or 10-fluoro-dihydro-7-hydroxymitragynine.

Timeline

The Drug Enforcement Administration conducted a three-factor analysis dated May 2026 regarding mitragynine pseudoindoxyl, MGM-15, and MGM-16. The agency published a notice of intent to temporarily schedule mitragynine pseudoindoxyl, MGM-15, and MGM-16 in the Federal Register on July 6, 2026. On August 24, 2026, the Drug Enforcement Administration issued a temporary scheduling order placing mitragynine pseudoindoxyl, MGM-15, and MGM-16 in Schedule I of the Controlled Substances Act.

The agency determined that placing mitragynine pseudoindoxyl, MGM-15, and MGM-16 in Schedule I is necessary to avoid an imminent hazard to public safety. The temporary order imposes regulatory controls and administrative, civil, and criminal sanctions applicable to Schedule I controlled substances on persons who handle or propose to handle mitragynine pseudoindoxyl, MGM-15, and MGM-16.

What's New

Additional reporting identifies the Drug Enforcement Administration as a United States federal law enforcement agency.

How Sources Differ

The DEA Docket No. DEA-1644 Temporary Scheduling Order states that the Drug Enforcement Administration published a notice of intent to temporarily schedule mitragynine pseudoindoxyl, MGM-15, and MGM-16 in the Federal Register on July 6, 2026. Wikidata states that the Drug Enforcement Administration is a United States federal law enforcement agency.

Why It Matters

The temporary scheduling order places specific chemical compounds under strict federal control due to an identified imminent hazard to public safety. By classifying mitragynine pseudoindoxyl, MGM-15, and MGM-16 as Schedule I substances, the Drug Enforcement Administration applies the highest level of regulatory scrutiny available under the Controlled Substances Act.

This action triggers administrative, civil, and criminal sanctions for any person who handles or proposes to handle these substances. The order covers not only the primary compounds but also their potential isomers, esters, ethers, and salts, ensuring broad regulatory coverage. The temporary nature of the order, effective until August 26, 2028, allows for immediate risk mitigation while longer-term scheduling processes may proceed.