OMAHA — Individuals are combining allergy medication with Pepcid AC to address premenstrual syndrome (PMS) symptoms. This practice has gained traction among TikTok users who assert its effectiveness in combating these symptoms.

There have been no clinical trials to test the safety or effectiveness of using this combination for PMS. Leigh A. Frame, executive director of the Office of Integrative Medicine & Health at George Washington University, stated, "This is basically an evidence-free zone." Frame added, "There's no evidence that it does or doesn't work."

Terese Hansen of Omaha, Nebraska, experienced persistent nausea, heartburn, and erratic body temperature for four years, with symptoms worsening around her period. "I could not be around anyone because I knew I was unpleasant," Hansen said. After consulting her doctor, Hansen decided to try the medication combination. She reported improvements in her physical symptoms, energy, and mood. "It was nuts," Hansen recalled. "My kids noticed, my boyfriend noticed. My boss noticed."

Pepcid AC and allergy pills function as histamine blockers, affecting different receptors throughout the body. Estrogen stimulates the release of histamine, while progesterone acts as a natural antihistamine. Progesterone levels decrease in the days leading up to menstruation. Histamine is associated with hormonal fluctuations, sleep disturbances, and thyroid problems.

However, antihistamines carry potential side effects, including drowsiness, fatigue, dry mouth, gastrointestinal issues, and adverse drug interactions. These medications pose higher risks for older adults and individuals with pre-existing kidney or liver conditions.

An increasing number of individuals are adopting a medication combination that lacks clinical evidence for its stated purpose. While anecdotal reports suggest perceived benefits, the absence of studies means the safety and efficacy for PMS treatment are unknown. Additionally, antihistamines have known side effects and can interact with other medications or exacerbate health conditions in certain populations.